5N2R

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with PSB36 at 2.8A resolution

5N2R の概要

• エントリーDOI: 10.2210/pdb5n2r/pdb
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562,ADENOSINE RECEPTOR A2A SOLUBLE CYTOCHROME B562 ADENOSINE RECEPTOR A2A,Adenosine receptor A2a, SODIUM ION, 1-butyl-3-[(~{E})-3-oxidanylprop-1-enyl]-8-[(1~{R},5~{S})-3-tricyclo[3.3.1.0^{3,7}]nonanyl]-7~{H}-purine-2,6-dione, ... (8 entities in total)
• 機能のキーワード: g-protein-coupled receptor, integral thermostabilizing mutations, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P29274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57428.64

構造登録者

Cheng, R.K.Y.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. (登録日: 2017-02-08, 公開日: 2017-07-26, 最終更新日: 2017-08-09)

• 主引用文献: Cheng, R.K.Y.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M.; Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.; Structure, 25:1275-1285.e4, 2017; PubMed: 28712806; DOI: 10.1016/j.str.2017.06.012

実験手法

X-RAY DIFFRACTION (2.8 Å)