5N2M

Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue

5N2M の概要

• エントリーDOI: 10.2210/pdb5n2m/pdb
• 分子名称: Bromodomain-containing protein 4, propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: transcription, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15647.02

構造登録者

Tallant, C.,Slavish, P.J.,Siejka, P.,Bharatham, N.,Shadrick, W.R.,Chai, S.,Young, B.M.,Boyd, V.A.,Heroven, C.,Wiggers, H.J.,Picaud, S.,Fedorov, O.,Krojer, T.,Chen, T.,Lee, R.E.,Guy, R.K.,Shelat, A.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2017-02-07, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

• 主引用文献: Tallant, C.,Slavish, P.J.,Siejka, P.,Bharatham, N.,Shadrick, W.R.,Chai, S.,Young, B.M.,Boyd, V.A.,Heroven, C.,Wiggers, H.J.,Picaud, S.,Fedorov, O.,Krojer, T.,Chen, T.,Lee, R.E.,Guy, R.K.,Shelat, A.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue; To Be Published,

実験手法

X-RAY DIFFRACTION (1.54 Å)