5N2K

Structure of unbound Briakinumab FAb

Summary for 5N2K

• Entry DOI: 10.2210/pdb5n2k/pdb
• Descriptor: Briakinumab FAb light chain, Briakinumab FAb heavy chain, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: antagonist, antibody, extracellular region, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 453186.69

Authors

Bloch, Y.,Savvides, S.N. (deposition date: 2017-02-07, release date: 2018-01-03, Last modification date: 2024-05-01)

• Primary citation: Bloch, Y.,Bouchareychas, L.,Merceron, R.,Skladanowska, K.,Van den Bossche, L.,Detry, S.,Govindarajan, S.,Elewaut, D.,Haerynck, F.,Dullaers, M.,Adamopoulos, I.E.,Savvides, S.N.; Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.; Immunity, 48:45-58.e6, 2018; PubMed: 29287995; DOI: 10.1016/j.immuni.2017.12.008

Experimental method

X-RAY DIFFRACTION (2.219 Å)