5MZP
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with caffeine at 2.1A resolution
Summary for 5MZP
Entry DOI | 10.2210/pdb5mzp/pdb |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, CAFFEINE, ... (8 entities in total) |
Functional Keywords | g-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutations, membrane protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P29274 |
Total number of polymer chains | 1 |
Total formula weight | 57490.71 |
Authors | Cheng, K.Y.R.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. (deposition date: 2017-02-01, release date: 2017-07-26, Last modification date: 2024-01-17) |
Primary citation | Cheng, R.K.Y.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure, 25:1275-1285.e4, 2017 Cited by PubMed: 28712806DOI: 10.1016/j.str.2017.06.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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