5MYX

Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18

5MYX の概要

• エントリーDOI: 10.2210/pdb5myx/pdb
• 分子名称: Fab c#24 light chain, Fab c#24 heavy chain, Pyroglutamate-Abeta pE3-18, ... (4 entities in total)
• 機能のキーワード: alzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 105330.25

構造登録者

Parthier, C.,Piechotta, A.,Stubbs, M.T. (登録日: 2017-01-30, 公開日: 2017-06-28, 最終更新日: 2024-01-17)

• 主引用文献: Piechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T.; Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.; J. Biol. Chem., 292:12713-12724, 2017; PubMed: 28623233; DOI: 10.1074/jbc.M117.777839

実験手法

X-RAY DIFFRACTION (1.492 Å)