5MXQ

Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-90 Inhibitor

5MXQ の概要

• エントリーDOI: 10.2210/pdb5mxq/pdb
• 分子名称: Beta-lactamase VIM-2, ZINC ION, 3-(phenylsulfonylamino)pyridine-2-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: metallo-beta-lactamase fold, zinc-dependent hydrolase, pfam00753, alpha-beta-beta-alpha sandwich, metallo-beta-lactamase inhibitor, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25307.49

構造登録者

Docquier, J.D.,De Luca, F.,Benvenuti, M.,Di Pisa, F.,Pozzi, C.,Mangani, S. (登録日: 2017-01-24, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

主引用文献

Leiris, S.,Coelho, A.,Castandet, J.,Bayet, M.,Lozano, C.,Bougnon, J.,Bousquet, J.,Everett, M.,Lemonnier, M.,Sprynski, N.,Zalacain, M.,Pallin, T.D.,Cramp, M.C.,Jennings, N.,Raphy, G.,Jones, M.W.,Pattipati, R.,Shankar, B.,Sivasubrahmanyam, R.,Soodhagani, A.K.,Juventhala, R.R.,Pottabathini, N.,Pothukanuri, S.,Benvenuti, M.,Pozzi, C.,Mangani, S.,De Luca, F.,Cerboni, G.,Docquier, J.D.,Davies, D.T.
SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.
Acs Infect Dis., 5:131-140, 2019

PubMed Abstract: The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors to be used in conjunction with carbapenems and other β-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-β-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem.

PubMed: 30427656
DOI: 10.1021/acsinfecdis.8b00246

実験手法

X-RAY DIFFRACTION (2 Å)