5MWZ

Crystal structure of the human BRPF1 bromodomain in complex with BZ073

Summary for 5MWZ

Entry DOI	10.2210/pdb5mwz/pdb
Descriptor	Peregrin, ~{N}-[1,4-diethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-2-(4-methylpiperazin-1-yl)ethanamide (3 entities in total)
Functional Keywords	bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14160.28
Authors	Zhu, J.,Caflisch, A. (deposition date: 2017-01-20, release date: 2018-02-14, Last modification date: 2019-10-16)
Primary citation	Zhu, J.,Zhou, C.,Caflisch, A. Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155:337-352, 2018 Cited by PubMed: 29902720 DOI: 10.1016/j.ejmech.2018.05.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation