5MWP
The structure of MR in complex with AZD9977.
Summary for 5MWP
Entry DOI | 10.2210/pdb5mwp/pdb |
Descriptor | Mineralocorticoid receptor, NCOA1 peptide, 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide, ... (4 entities in total) |
Functional Keywords | signaling protein, nuclear hormone receptor, ligand complex, peptide complex |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 2 |
Total formula weight | 36932.01 |
Authors | Edman, K.,Aagaard, A.,Backstrom, S. (deposition date: 2017-01-19, release date: 2018-03-07, Last modification date: 2024-01-17) |
Primary citation | Bamberg, K.,Johansson, U.,Edman, K.,William-Olsson, L.,Myhre, S.,Gunnarsson, A.,Geschwindner, S.,Aagaard, A.,Bjornson Granqvist, A.,Jaisser, F.,Huang, Y.,Granberg, K.L.,Jansson-Lofmark, R.,Hartleib-Geschwindner, J. Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion. PLoS ONE, 13:e0193380-e0193380, 2018 Cited by PubMed: 29474466DOI: 10.1371/journal.pone.0193380 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
Download full validation report