5MWJ

Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1

5MWJ の概要

• エントリーDOI: 10.2210/pdb5mwj/pdb
• 分子名称: Transducin-like enhancer protein 1, DIMETHYL SULFOXIDE, pepide inhibtor, ... (4 entities in total)
• 機能のキーワード: transducin-like; constrained peptide inhibitor; transcriptional corepressor, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75475.07

構造登録者

McGrath, S.,Tortorici, M.,Vidler, L.,Drouin, L.,Westwood, I.,Gimeson, P.,Van Montfort, R.,Hoelder, S. (登録日: 2017-01-18, 公開日: 2017-04-05, 最終更新日: 2024-01-17)

• 主引用文献: McGrath, S.,Tortorici, M.,Drouin, L.,Solanki, S.,Vidler, L.,Westwood, I.,Gimeson, P.,Van Montfort, R.,Hoelder, S.; Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.; Chemistry, 23:9577-9584, 2017; PubMed: 28326635; DOI: 10.1002/chem.201700747

実験手法

X-RAY DIFFRACTION (2.04 Å)