5MV4

ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23)

Summary for 5MV4

Entry DOI	10.2210/pdb5mv4/pdb
Descriptor	ACC1 antibody Fab fragment, heavy chain, ACC1 antibody Fab fragment, light chain, synthetic peptide containing the citrullinated collagen type II epitope CII616-639,Collagen alpha-1(II) chain,synthetic peptide containing the citrullinated collagen type II epitope CII616-639, ... (5 entities in total)
Functional Keywords	anti-citrullinated protein antibody (acpa) fab fragment collagen type ii citrullinated c1 epitope, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	24
Total formula weight	410469.96
Authors	Dobritzsch, D.,Holmdahl, R.,Ge, C. (deposition date: 2017-01-15, release date: 2017-07-19, Last modification date: 2024-01-17)
Primary citation	Ge, C.,Tong, D.,Liang, B.,Lonnblom, E.,Schneider, N.,Hagert, C.,Viljanen, J.,Ayoglu, B.,Stawikowska, R.,Nilsson, P.,Fields, G.B.,Skogh, T.,Kastbom, A.,Kihlberg, J.,Burkhardt, H.,Dobritzsch, D.,Holmdahl, R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight, 2:-, 2017 Cited by PubMed: 28679953 DOI: 10.1172/jci.insight.93688 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation