5MUF
Crystal structure of human phosphoglycerate mutase family member 5 (PGAM5) in its enzymatically active dodecameric form induced by the presence of the N-terminal WDPNWD motif
Summary for 5MUF
Entry DOI | 10.2210/pdb5muf/pdb |
Related | 3MXO 3O0T |
Descriptor | Serine/threonine-protein phosphatase PGAM5, mitochondrial, PHOSPHATE ION (3 entities in total) |
Functional Keywords | phosphoglycerate mutase family member 5, pgam5, serine/threonine phosphatase, mitochondrial protein, hydrolase, wdpnwd motif, wdxnwd motif, dimer, dodecamer, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion outer membrane ; Single-pass membrane protein : Q96HS1 |
Total number of polymer chains | 3 |
Total formula weight | 81701.60 |
Authors | Chaikuad, A.,Alfano, I.,Picaud, S.,Filippakopoulos, P.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-13, release date: 2017-07-12, Last modification date: 2024-01-17) |
Primary citation | Chaikuad, A.,Filippakopoulos, P.,Marcsisin, S.R.,Picaud, S.,Schroder, M.,Sekine, S.,Ichijo, H.,Engen, J.R.,Takeda, K.,Knapp, S. Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure, 25:1089-1099.e3, 2017 Cited by PubMed: 28648608DOI: 10.1016/j.str.2017.05.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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