5MS4

Kallikrein-related peptidase 8 leupeptin inhibitor complex

Summary for 5MS4

• Entry DOI: 10.2210/pdb5ms4/pdb
• Related PRD ID: PRD_000216
• Descriptor: Kallikrein-8, LEUPEPTIN, TERTIARY-BUTYL ALCOHOL, ... (5 entities in total)
• Functional Keywords: trypsin-like serine protease, aldehyde inhibitor, ca2+ complex, synaptic remodeling, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 100039.45

Authors

Debela, M.,Magdolen, V.,Skala, W.,Bode, W.,Brandstetter, H.,Goettig, P. (deposition date: 2016-12-30, release date: 2018-01-17, Last modification date: 2019-10-09)

• Primary citation: Debela, M.,Magdolen, V.,Skala, W.,Elsasser, B.,Schneider, E.L.,Craik, C.S.,Biniossek, M.L.,Schilling, O.,Bode, W.,Brandstetter, H.,Goettig, P.; Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.; Sci Rep, 8:10705-10705, 2018; PubMed: 30013126; DOI: 10.1038/s41598-018-29058-6

Experimental method

X-RAY DIFFRACTION (2.1 Å)