5MRV

Crystal structure of human carboxypeptidase O in complex with NvCI

Summary for 5MRV

Entry DOI	10.2210/pdb5mrv/pdb
Descriptor	Carboxypeptidase O, Metallocarboxypeptidase inhibitor, ZINC ION, ... (5 entities in total)
Functional Keywords	digestive metallocarboxypeptidase, food digestion, carboxypeptidase inhibitor, brush border enzyme, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Apical cell membrane ; Lipid-anchor, GPI-anchor : Q8IVL8
Total number of polymer chains	3
Total formula weight	89009.27
Authors	Garcia-Pardo, J.,Garcia-Guerrero, M.C.,Fernandez-Alvarez, R.,Lyons, P.,Aviles, F.X.,Lorenzo, J.,Reverter, D. (deposition date: 2016-12-27, release date: 2018-01-17, Last modification date: 2024-01-17)
Primary citation	Garcia-Guerrero, M.C.,Garcia-Pardo, J.,Berenguer, E.,Fernandez-Alvarez, R.,Barfi, G.B.,Lyons, P.J.,Aviles, F.X.,Huber, R.,Lorenzo, J.,Reverter, D. Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proc. Natl. Acad. Sci. U.S.A., 115:E3932-E3939, 2018 Cited by PubMed: 29636417 DOI: 10.1073/pnas.1803685115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.854 Å)

Structure validation