5MRI
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18
Summary for 5MRI
Entry DOI | 10.2210/pdb5mri/pdb |
Descriptor | Sortilin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | vps10p, receptor, sortilin, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 79235.28 |
Authors | Andersen, J.L.,Strandbygaard, D.,Thirup, S. (deposition date: 2016-12-23, release date: 2017-05-17, Last modification date: 2024-01-17) |
Primary citation | Andersen, J.L.,Lindberg, S.,Langgard, M.,Maltas, P.J.,Ronn, L.C.B.,Bundgaard, C.,Strandbygaard, D.,Thirup, S.,Watson, S.P. The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27:2629-2633, 2017 Cited by PubMed: 28462834DOI: 10.1016/j.bmcl.2017.02.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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