5MRA

human SCBD (sorcin calcium binding domain) in complex with doxorubicin

Summary for 5MRA

Entry DOI	10.2210/pdb5mra/pdb
Descriptor	Sorcin, MAGNESIUM ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	sorcin (soluble resistance-related calcium binding protein), metal binding protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P30626
Total number of polymer chains	4
Total formula weight	76258.02
Authors	Ilari, A.,Fiorillo, A.,Colotti, G.,Genovese, I. (deposition date: 2016-12-22, release date: 2017-11-29, Last modification date: 2024-01-17)
Primary citation	Genovese, I.,Fiorillo, A.,Ilari, A.,Masciarelli, S.,Fazi, F.,Colotti, G. Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells. Cell Death Dis, 8:e2950-e2950, 2017 Cited by PubMed: 28726784 DOI: 10.1038/cddis.2017.342 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.74 Å)

Structure validation