5MOY

Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C

Summary for 5MOY

• Entry DOI: 10.2210/pdb5moy/pdb
• Related: 4jra
• Descriptor: Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: beta-helix, vesicles, lumen, toxin, hydrolase, botox
• Biological source: Clostridium botulinum; More
• Cellular location: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: Q45894; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein : Q496J9
• Total number of polymer chains: 2
• Total formula weight: 66061.77

Authors

Benoit, R.M.,Scharer, M.A. (deposition date: 2016-12-14, release date: 2017-03-15, Last modification date: 2024-01-17)

• Primary citation: Benoit, R.M.,Scharer, M.A.,Wieser, M.M.,Li, X.,Frey, D.,Kammerer, R.A.; Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.; Sci Rep, 7:43588-43588, 2017; PubMed: 28252640; DOI: 10.1038/srep43588

Experimental method

X-RAY DIFFRACTION (2.302 Å)