5MMS

Human cystathionine beta-synthase (CBS) p.P49L delta409-551 variant

5MMS の概要

• エントリーDOI: 10.2210/pdb5mms/pdb
• 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: cystathionine beta-synthase, hydrogen sulfide, transsulfuration, classical homocystinuria, lyase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P35520
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 273654.91

構造登録者

Vicente, J.B.,Colaco, H.G.,Malagrino, F.,Santo, P.E.,Gutierres, A.,Bandeiras, T.M.,Leandro, P.,Brito, J.A.,Giuffre, A. (登録日: 2016-12-12, 公開日: 2017-05-03, 最終更新日: 2024-01-17)

• 主引用文献: Vicente, J.B.,Colaco, H.G.,Malagrino, F.,Santo, P.E.,Gutierres, A.,Bandeiras, T.M.,Leandro, P.,Brito, J.A.,Giuffre, A.; A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine beta-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?; Oxid Med Cell Longev, 2017:8940321-8940321, 2017; PubMed: 28421128; DOI: 10.1155/2017/8940321

実験手法

X-RAY DIFFRACTION (2.8 Å)