5MME
Crystal structure of CREBBP bromodomain complexd with US46C
Summary for 5MME
Entry DOI | 10.2210/pdb5mme/pdb |
Descriptor | CREB-binding protein, dimethyl 5-[(5-ethanoyl-2-ethoxy-phenyl)amino]benzene-1,3-dicarboxylate (3 entities in total) |
Functional Keywords | inhibitor, bromodomain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 29189.47 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2016-12-09, release date: 2017-12-20, Last modification date: 2024-01-17) |
Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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