5ML5
Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b
Summary for 5ML5
Entry DOI | 10.2210/pdb5ml5/pdb |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{H}-imidazol-5-yl]pyridin-2-yl]propanamide, ... (4 entities in total) |
Functional Keywords | kinase, p38alpha, inhibitor, complex, ck1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42712.87 |
Authors | Buehrmann, M.,Rauh, D. (deposition date: 2016-12-06, release date: 2017-04-05, Last modification date: 2024-05-08) |
Primary citation | Halekotte, J.,Witt, L.,Ianes, C.,Kruger, M.,Buhrmann, M.,Rauh, D.,Pichlo, C.,Brunstein, E.,Luxenburger, A.,Baumann, U.,Knippschild, U.,Bischof, J.,Peifer, C. Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK. Molecules, 22:-, 2017 Cited by PubMed: 28338621DOI: 10.3390/molecules22040522 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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