5ML5

Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b

5ML5 の概要

• エントリーDOI: 10.2210/pdb5ml5/pdb
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{H}-imidazol-5-yl]pyridin-2-yl]propanamide, ... (4 entities in total)
• 機能のキーワード: kinase, p38alpha, inhibitor, complex, ck1, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42712.87

構造登録者

Buehrmann, M.,Rauh, D. (登録日: 2016-12-06, 公開日: 2017-04-05, 最終更新日: 2020-07-29)

• 主引用文献: Halekotte, J.,Witt, L.,Ianes, C.,Kruger, M.,Buhrmann, M.,Rauh, D.,Pichlo, C.,Brunstein, E.,Luxenburger, A.,Baumann, U.,Knippschild, U.,Bischof, J.,Peifer, C.; Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK.; Molecules, 22:-, 2017; PubMed: 28338621; DOI: 10.3390/molecules22040522

実験手法

X-RAY DIFFRACTION (1.9 Å)