5MKV
Crystal Structure of Human Dihydropyrimidinease-like 2 (DPYSL2A)/Collapsin Response Mediator Protein (CRMP2) residues 13-516
Summary for 5MKV
Entry DOI | 10.2210/pdb5mkv/pdb |
Descriptor | Dihydropyrimidinase-related protein 2, 1,2-ETHANEDIOL (3 entities in total) |
Functional Keywords | crmp2, ovarian cancer, microtubule associated protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 221782.12 |
Authors | Sethi, R.,Zheng, Y.,Krojer, T.,Velupillai, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Ahmed, A.A.,von Delft, F. (deposition date: 2016-12-05, release date: 2017-02-22, Last modification date: 2024-01-17) |
Primary citation | Zheng, Y.,Sethi, R.,Mangala, L.S.,Taylor, C.,Goldsmith, J.,Wang, M.,Masuda, K.,Karaminejadranjbar, M.,Mannion, D.,Miranda, F.,Herrero-Gonzalez, S.,Hellner, K.,Chen, F.,Alsaadi, A.,Albukhari, A.,Fotso, D.C.,Yau, C.,Jiang, D.,Pradeep, S.,Rodriguez-Aguayo, C.,Lopez-Berestein, G.,Knapp, S.,Gray, N.S.,Campo, L.,Myers, K.A.,Dhar, S.,Ferguson, D.,Bast, R.C.,Sood, A.K.,von Delft, F.,Ahmed, A.A. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Nat Commun, 9:476-476, 2018 Cited by PubMed: 29396402DOI: 10.1038/s41467-017-02811-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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