5MJU

Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor TFB-TBOA and the allosteric inhibitor UCPH101

5MJU の概要

• エントリーDOI: 10.2210/pdb5mju/pdb
• 分子名称: Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid (3 entities in total)
• 機能のキーワード: excitatory aminoacid transporter 1, human glutamate transporter, tfb-tboa, ucph-101, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Multi-pass membrane protein: P43003
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57361.20

構造登録者

Canul-Tec, J.,Assal, R.,Legrand, P.,Reyes, N. (登録日: 2016-12-01, 公開日: 2017-04-19, 最終更新日: 2024-01-17)

• 主引用文献: Canul-Tec, J.C.,Assal, R.,Cirri, E.,Legrand, P.,Brier, S.,Chamot-Rooke, J.,Reyes, N.; Structure and allosteric inhibition of excitatory amino acid transporter 1.; Nature, 544:446-451, 2017; PubMed: 28424515; DOI: 10.1038/nature22064

実験手法

X-RAY DIFFRACTION (3.71 Å)