5MHP
Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
Summary for 5MHP
Entry DOI | 10.2210/pdb5mhp/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, PHOSPHATE ION, 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, ... (12 entities in total) |
Functional Keywords | atx, inhibitor, enpp2, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : Q13822 |
Total number of polymer chains | 1 |
Total formula weight | 102845.24 |
Authors | Fleury, D.,Mueller, I.,Lamers, M.,Triballeau, N.,Mollat, P.,Vercheval, L. (deposition date: 2016-11-25, release date: 2017-08-30, Last modification date: 2024-01-17) |
Primary citation | Desroy, N.,Housseman, C.,Bock, X.,Joncour, A.,Bienvenu, N.,Cherel, L.,Labeguere, V.,Rondet, E.,Peixoto, C.,Grassot, J.M.,Picolet, O.,Annoot, D.,Triballeau, N.,Monjardet, A.,Wakselman, E.,Roncoroni, V.,Le Tallec, S.,Blanque, R.,Cottereaux, C.,Vandervoort, N.,Christophe, T.,Mollat, P.,Lamers, M.,Auberval, M.,Hrvacic, B.,Ralic, J.,Oste, L.,van der Aar, E.,Brys, R.,Heckmann, B. Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. J. Med. Chem., 60:3580-3590, 2017 Cited by PubMed: 28414242DOI: 10.1021/acs.jmedchem.7b00032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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