5MGQ

Solution structure of oxidized and amidated human IAPP (1-37), the diabetes II peptide.

Summary for 5MGQ

• Entry DOI: 10.2210/pdb5mgq/pdb
• NMR Information: BMRB: 34069
• Descriptor: Islet amyloid polypeptide (1 entity in total)
• Functional Keywords: recombinant human iapp, type ii diabetes, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 3908.32

Authors

Rodriguez Camargo, D.C.,Tripsianes, K.,Reif, B. (deposition date: 2016-11-21, release date: 2017-03-29, Last modification date: 2023-06-14)

• Primary citation: Rodriguez Camargo, D.C.,Tripsianes, K.,Buday, K.,Franko, A.,Gobl, C.,Hartlmuller, C.,Sarkar, R.,Aichler, M.,Mettenleiter, G.,Schulz, M.,Boddrich, A.,Erck, C.,Martens, H.,Walch, A.K.,Madl, T.,Wanker, E.E.,Conrad, M.,de Angelis, M.H.,Reif, B.; The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.; Sci Rep, 7:44041-44041, 2017; PubMed: 28287098; DOI: 10.1038/srep44041

Experimental method

SOLUTION NMR