5MGH

Crystal structure of pathogenic mutants of human mitochodnrial PheRS

5MGH の概要

• エントリーDOI: 10.2210/pdb5mgh/pdb
• 分子名称: Phenylalanine--tRNA ligase, mitochondrial, PHENYLALANINE (3 entities in total)
• 機能のキーワード: crystal structure of pathogenic human mitochondrial phers, molecular dynamic, kinetik study, aminoacylation, ligase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47611.00

構造登録者

Kartvelishvili, E.,Tworowski, D.,Vernon, H.,Chrzanowska-Lightowlers, Z.,Moor, N.,Wang, J.,Wong, L.-J.,Safro, M. (登録日: 2016-11-21, 公開日: 2017-05-03, 最終更新日: 2024-05-08)

• 主引用文献: Kartvelishvili, E.,Tworowski, D.,Vernon, H.,Moor, N.,Wang, J.,Wong, L.J.,Chrzanowska-Lightowlers, Z.,Safro, M.; Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.; Protein Sci., 26:1505-1516, 2017; PubMed: 28419689; DOI: 10.1002/pro.3176

実験手法

X-RAY DIFFRACTION (1.87 Å)