5MG2

Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe

5MG2 の概要

• エントリーDOI: 10.2210/pdb5mg2/pdb
• 分子名称: Transcription initiation factor TFIID subunit 1, 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, ... (4 entities in total)
• 機能のキーワード: transcription, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P21675
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16498.48

構造登録者

Tallant, C.,Bouche, L.,Holton, S.J.,Fedorov, O.,Siejka, P.,Picaud, S.,Krojer, T.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Hartung, I.V.,Haendler, B.,Muller, S.,Huber, K.V.M.,Structural Genomics Consortium (SGC) (登録日: 2016-11-20, 公開日: 2017-05-03, 最終更新日: 2024-01-17)

• 主引用文献: Bouche, L.,Christ, C.D.,Siegel, S.,Fernandez-Montalvan, A.E.,Holton, S.J.,Fedorov, O.,Ter Laak, A.,Sugawara, T.,Stockigt, D.,Tallant, C.,Bennett, J.,Monteiro, O.,Diaz-Saez, L.,Siejka, P.,Meier, J.,Putter, V.,Weiske, J.,Muller, S.,Huber, K.V.M.,Hartung, I.V.,Haendler, B.; Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.; J. Med. Chem., 60:4002-4022, 2017; PubMed: 28402630; DOI: 10.1021/acs.jmedchem.7b00306

実験手法

X-RAY DIFFRACTION (1.75 Å)