5MFQ

Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution

5MFQ の概要

• エントリーDOI: 10.2210/pdb5mfq/pdb
• 分子名称: Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ... (7 entities in total)
• 機能のキーワード: ionotropic glutamate receptor, gluk1 ligand-binding domain, membrane protein, positive allosteric modulator
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59631.77

構造登録者

Larsen, A.P.,Frydenvang, K.,Kastrup, J.S. (登録日: 2016-11-18, 公開日: 2017-04-12, 最終更新日: 2024-01-17)

• 主引用文献: Larsen, A.P.,Fievre, S.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Kastrup, J.S.,Mulle, C.; Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.; Mol. Pharmacol., 91:576-585, 2017; PubMed: 28360094; DOI: 10.1124/mol.116.107599

実験手法

X-RAY DIFFRACTION (1.9 Å)