5MEI

Crystal structure of Agelastatin A bound to the 80S ribosome

これはPDB形式変換不可エントリーです。

5MEI の概要

• エントリーDOI: 10.2210/pdb5mei/pdb
• 分子名称: 25S ribosomal RNA, 60S ribosomal protein L8-A, 60S ribosomal protein L9-A, ... (87 entities in total)
• 機能のキーワード: 80s ribosome, protein synthesis inhibitor, ribosome
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 詳細
• 細胞内の位置: Cytoplasm : P17076 P05738 P41805 Q3E757 Q12690 P36105 P05748 P26784 P05740 P0CX49 P0CX82 P0CX23 Q02753 P05749 P0CX41 P04449 P04456 P05743 P0C2H6 P02406 P05747 P14120 P0C2H8 P38061 P05744 P87262 P0CX84 P05745 P49166 P0CX45 P49167 P04650 P0CX87 P0CX27 P0CX25 P39015 P05317 P14126 P32905 P33442 P25443 P05750 P0CX35 P26783 P0CX37 P26786 P0CX39 O13516 P10664 Q08745 P0CX47 P48589 P05756 P39516 Q01855 P0CX51 P14127 P0CX55 P07280 P26321 P38701 P0C0V8 P0C0W1 P0CX29 P0CX31 Q3E792 P39939 P35997 Q3E7X9 P41057 Q02326 P0CX33 P38011 P02407 P05737; Ubiquitin: Cytoplasm . 60S ribosomal protein L40-A: Cytoplasm : P0CH08; Ubiquitin: Cytoplasm . 40S ribosomal protein S31: Cytoplasm : P05759 P05759
• タンパク質・核酸の鎖数: 159
• 化学式量合計: 6450160.35

構造登録者

McClary, B.,Zinshteyn, B.,Meyer, M.,Jouanneau, M.,Pellegrino, S.,Yusupova, G.,Schuller, A.,Reyes, J.C.P.,Lu, J.,Luo, C.,Dang, Y.,Romo, D.,Yusupov, M.,Green, R.,Liu, J.O. (登録日: 2016-11-15, 公開日: 2017-06-28, 最終更新日: 2024-01-17)

• 主引用文献: McClary, B.,Zinshteyn, B.,Meyer, M.,Jouanneau, M.,Pellegrino, S.,Yusupova, G.,Schuller, A.,Reyes, J.C.P.,Lu, J.,Guo, Z.,Ayinde, S.,Luo, C.,Dang, Y.,Romo, D.,Yusupov, M.,Green, R.,Liu, J.O.; Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.; Cell Chem Biol, 24:605-613.e5, 2017; PubMed: 28457705; DOI: 10.1016/j.chembiol.2017.04.006

実験手法

X-RAY DIFFRACTION (3.5 Å)