5MAT
Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor
Summary for 5MAT
Entry DOI | 10.2210/pdb5mat/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, (7~{R})-7-[(3,5-dimethyl-1,2-oxazol-4-yl)methylamino]-3-[(4-methoxynaphthalen-1-yl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one, ... (7 entities in total) |
Functional Keywords | nad-dependent protein deacylase, sirtuin, inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6 |
Total number of polymer chains | 2 |
Total formula weight | 71172.22 |
Authors | Moniot, S.,Steegborn, C. (deposition date: 2016-11-04, release date: 2017-02-08, Last modification date: 2024-01-17) |
Primary citation | Sundriyal, S.,Moniot, S.,Mahmud, Z.,Yao, S.,Di Fruscia, P.,Reynolds, C.R.,Dexter, D.T.,Sternberg, M.J.,Lam, E.W.,Steegborn, C.,Fuchter, M.J. Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. J. Med. Chem., 60:1928-1945, 2017 Cited by PubMed: 28135086DOI: 10.1021/acs.jmedchem.6b01690 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.069 Å) |
Structure validation
Download full validation report