5MAT
Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor
5MAT の概要
エントリーDOI | 10.2210/pdb5mat/pdb |
分子名称 | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, (7~{R})-7-[(3,5-dimethyl-1,2-oxazol-4-yl)methylamino]-3-[(4-methoxynaphthalen-1-yl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one, ... (7 entities in total) |
機能のキーワード | nad-dependent protein deacylase, sirtuin, inhibitor complex, hydrolase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 71172.22 |
構造登録者 | |
主引用文献 | Sundriyal, S.,Moniot, S.,Mahmud, Z.,Yao, S.,Di Fruscia, P.,Reynolds, C.R.,Dexter, D.T.,Sternberg, M.J.,Lam, E.W.,Steegborn, C.,Fuchter, M.J. Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. J. Med. Chem., 60:1928-1945, 2017 Cited by PubMed: 28135086DOI: 10.1021/acs.jmedchem.6b01690 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.069 Å) |
構造検証レポート
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