5MAE

CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide

5MAE の概要

• エントリーDOI: 10.2210/pdb5mae/pdb
• 分子名称: Cathepsin L1, [4-[cyclopentyl(pyrazin-2-ylmethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]methylideneazanide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Lysosome: P07711
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24807.40

構造登録者

Kuglstatter, A.,Stihle, M.,Benz, J. (登録日: 2016-11-03, 公開日: 2017-01-11, 最終更新日: 2024-05-01)

• 主引用文献: Giroud, M.,Ivkovic, J.,Martignoni, M.,Fleuti, M.,Trapp, N.,Haap, W.,Kuglstatter, A.,Benz, J.,Kuhn, B.,Schirmeister, T.,Diederich, F.; Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.; ChemMedChem, 12:257-270, 2017; PubMed: 27992115; DOI: 10.1002/cmdc.201600563

実験手法

X-RAY DIFFRACTION (1 Å)