5M6R

Human porphobilinogen deaminase in complex with reaction intermediate

Summary for 5M6R

DescriptorPorphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsporphobilinogen deaminase, heme biosynthesis, porphyria, hmbs, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight87638.27
Authors
Pluta, P.,Millet, O.,Roversi, P.,Rojas, A.L.,Gu, S. (deposition date: 2016-10-25, release date: 2017-11-15, Last modification date: 2019-05-29)
Primary citation
Pluta, P.,Roversi, P.,Bernardo-Seisdedos, G.,Rojas, A.L.,Cooper, J.B.,Gu, S.,Pickersgill, R.W.,Millet, O.
Structural basis of pyrrole polymerization in human porphobilinogen deaminase.
Biochim Biophys Acta Gen Subj, 1862:1948-1955, 2018
PubMed: 29908816 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbagen.2018.06.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.73 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2631 0.5% 2.3% 11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload