5M6R

Human porphobilinogen deaminase in complex with reaction intermediate

Summary for 5M6R

DescriptorPorphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsporphobilinogen deaminase, heme biosynthesis, porphyria, hmbs, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P08397
Total number of polymer chains2
Total molecular weight87638.27
Authors
Pluta, P.,Millet, O.,Roversi, P.,Rojas, A.L.,Gu, S. (deposition date: 2016-10-25, release date: 2017-11-15, Last modification date: 2018-01-31)
Primary citation
Pluta, P.,Millet, O.,Roversi, P.,Rojas, A.L.,Gu, S.
Human Porphobilinogen deaminase in complex with reaction intermediate
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.73 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26310.5%2.3%11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5m6r
no rotation
Molmil generated image of 5m6r
rotated about x axis by 90°
Molmil generated image of 5m6r
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 5m6r
no rotation
Molmil generated image of 5m6r
rotated about x axis by 90°
Molmil generated image of 5m6r
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5m6r.pdb1.gz [234.16 KB])
Coordinate files for Biological unit (5m6r.pdb2.gz [220.9 KB])