5M6R

Human porphobilinogen deaminase in complex with reaction intermediate

5M6R の概要

• エントリーDOI: 10.2210/pdb5m6r/pdb
• 分子名称: Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: porphobilinogen deaminase, heme biosynthesis, porphyria, hmbs, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87638.27

構造登録者

Pluta, P.,Millet, O.,Roversi, P.,Rojas, A.L.,Gu, S. (登録日: 2016-10-25, 公開日: 2017-11-15, 最終更新日: 2024-01-17)

• 主引用文献: Pluta, P.,Roversi, P.,Bernardo-Seisdedos, G.,Rojas, A.L.,Cooper, J.B.,Gu, S.,Pickersgill, R.W.,Millet, O.; Structural basis of pyrrole polymerization in human porphobilinogen deaminase.; Biochim Biophys Acta Gen Subj, 1862:1948-1955, 2018; PubMed: 29908816; DOI: 10.1016/j.bbagen.2018.06.013

実験手法

X-RAY DIFFRACTION (2.73 Å)