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5M5A

Crystal structure of MELK in complex with an inhibitor

Summary for 5M5A
Entry DOI10.2210/pdb5m5a/pdb
DescriptorMaternal embryonic leucine zipper kinase, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordskinase, inhibitor, complex, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight40769.44
Authors
Canevari, G.,Re Depaolini, S.,Casale, E.,Felder, E.,Kuster, B.,Heinzlmeir, S. (deposition date: 2016-10-21, release date: 2017-12-06, Last modification date: 2019-04-24)
Primary citationKlaeger, S.,Heinzlmeir, S.,Wilhelm, M.,Polzer, H.,Vick, B.,Koenig, P.A.,Reinecke, M.,Ruprecht, B.,Petzoldt, S.,Meng, C.,Zecha, J.,Reiter, K.,Qiao, H.,Helm, D.,Koch, H.,Schoof, M.,Canevari, G.,Casale, E.,Depaolini, S.R.,Feuchtinger, A.,Wu, Z.,Schmidt, T.,Rueckert, L.,Becker, W.,Huenges, J.,Garz, A.K.,Gohlke, B.O.,Zolg, D.P.,Kayser, G.,Vooder, T.,Preissner, R.,Hahne, H.,Tonisson, N.,Kramer, K.,Gotze, K.,Bassermann, F.,Schlegl, J.,Ehrlich, H.C.,Aiche, S.,Walch, A.,Greif, P.A.,Schneider, S.,Felder, E.R.,Ruland, J.,Medard, G.,Jeremias, I.,Spiekermann, K.,Kuster, B.
The target landscape of clinical kinase drugs.
Science, 358:-, 2017
Cited by
PubMed: 29191878
DOI: 10.1126/science.aan4368
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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