5M4Z

Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate

Summary for 5M4Z

• Entry DOI: 10.2210/pdb5m4z/pdb
• Descriptor: Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: enzyme-inhibitor complex, high-resolution structure, anticancer target, transferase
• Biological source: Trichinella spiralis (Trichina worm)
• Total number of polymer chains: 2
• Total formula weight: 75591.64

Authors

Wilk, P.,Maj, P.,Jarmula, A.,Dowiercial, A.,Rode, W. (deposition date: 2016-10-19, release date: 2017-12-20, Last modification date: 2024-01-17)

• Primary citation: Maj, P.,Jarmula, A.,Wilk, P.,Prokopowicz, M.,Rypniewski, W.,Zielinski, Z.,Dowiercial, A.,Bzowska, A.,Rode, W.; Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.; Int J Mol Sci, 22:-, 2021; PubMed: 33946210; DOI: 10.3390/ijms22094758

Experimental method

X-RAY DIFFRACTION (1.179 Å)