5M39

Crystal structure of BRD4 BROMODOMAIN 1 IN COMPLEX WITH LIGAND 1

5M39 の概要

• エントリーDOI: 10.2210/pdb5m39/pdb
• 分子名称: Bromodomain-containing protein 4, 6-(3,4-dimethoxyphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine (3 entities in total)
• 機能のキーワード: bromodomain, brd4 bd1, epigenetic, histone reader, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30739.33

構造登録者

Kessler, D.,Mayer, M.,Engelhardt, H.,Wolkerstorfer, B.,Geist, L. (登録日: 2016-10-14, 公開日: 2017-09-27, 最終更新日: 2024-01-17)

• 主引用文献: Geist, L.,Mayer, M.,Cockcroft, X.L.,Wolkerstorfer, B.,Kessler, D.,Engelhardt, H.,McConnell, D.B.,Konrat, R.; Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design.; J. Med. Chem., 60:8708-8715, 2017; PubMed: 28910100; DOI: 10.1021/acs.jmedchem.7b00845

実験手法

X-RAY DIFFRACTION (1.38 Å)