5M1Z

STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR

5M1Z の概要

• エントリーDOI: 10.2210/pdb5m1z/pdb
• 分子名称: Exo-1,5-alpha-L-arabinofuranobiosidase, alpha-L-arabinofuranose-(1-5)-(Z)-L-Arabinonhydroximo-1,4-lactone, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: arabinofuramisodase, inhibitor, complex, hydrolase
• 由来する生物種: Gibberella zeae (Wheat head blight fungus)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42270.83

構造登録者

Varrot, A. (登録日: 2016-10-11, 公開日: 2016-12-28, 最終更新日: 2024-01-17)

主引用文献

Coyle, T.,Debowski, A.W.,Varrot, A.,Stubbs, K.A.
Exploiting sp(2) -Hybridisation in the Development of Potent 1,5-alpha-l-Arabinanase Inhibitors.
Chembiochem, 18:974-978, 2017

PubMed Abstract: The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity are described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis of the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases.

PubMed: 28266777
DOI: 10.1002/cbic.201700073

実験手法

X-RAY DIFFRACTION (2 Å)