5M0T

Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH

5M0T の概要

• エントリーDOI: 10.2210/pdb5m0t/pdb
• 分子名称: Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH, FE (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total)
• 機能のキーワード: cycloclavine biosynthesis, eash, alpha-ketoglutarate-dependent non-heme iron oxygenase, ergot alkaloids, oxidoreductase
• 由来する生物種: Aspergillus japonicus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65987.53

構造登録者

Jakubczyk, D.,Caputi, L.,Stevenson, C.E.M.,Lawson, D.M.,O'Connor, S.E. (登録日: 2016-10-05, 公開日: 2016-12-07, 最終更新日: 2024-01-17)

主引用文献

Jakubczyk, D.,Caputi, L.,Stevenson, C.E.,Lawson, D.M.,O'Connor, S.E.
Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.
Chem. Commun. (Camb.), 52:14306-14309, 2016

PubMed Abstract: Aj_EasH is a non-heme iron- and α-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 Å resolution) reported here provides insight into the mechanism of this unusual and complex reaction.

PubMed: 27885368
DOI: 10.1039/c6cc08438a

実験手法

X-RAY DIFFRACTION (2.2 Å)