5LWN

Crystal structure of JAK3 in complex with Compound 5 (FM409)

5LWN の概要

• エントリーDOI: 10.2210/pdb5lwn/pdb
• 分子名称: Tyrosine-protein kinase JAK3, 1-phenylurea, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: transferase, jak3, covalent inhibitor, reversible covalent inhibitor, induced pocket, arginine pocket, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : P52333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34812.88

構造登録者

Chaikuad, A.,Forster, M.,Mukhopadhyay, S.,Kupinska, K.,Ellis, K.,Mahajan, P.,Burgess-Brown, N.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Laufer, S.A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2016-09-18, 公開日: 2016-10-26, 最終更新日: 2016-11-30)

• 主引用文献: Forster, M.,Chaikuad, A.,Bauer, S.M.,Holstein, J.,Robers, M.B.,Corona, C.R.,Gehringer, M.,Pfaffenrot, E.,Ghoreschi, K.,Knapp, S.,Laufer, S.A.; Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.; Cell Chem Biol, 23:1335-1340, 2016; PubMed: 27840070; DOI: 10.1016/j.chembiol.2016.10.008

実験手法

X-RAY DIFFRACTION (1.6 Å)