5LVX

Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator

Summary for 5LVX

Entry DOI	10.2210/pdb5lvx/pdb
Descriptor	Glucosylceramidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	gcase, hydrolase, glycoprotein, glycosidase, glucosylceramidase, prot, proteros biostructures gmbh
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	230629.43
Authors	Zheng, J.,Chen, L.,Skinner, O.S.,Lansbury, P.,Skerlj, R.,Mrosek, M.,Heunisch, U.,Krapp, S.,Weigand, S.,Charrow, J.,Schwake, M.,Kelleher, N.L.,Silverman, R.B.,Krainc, D. (deposition date: 2016-09-14, release date: 2017-10-25, Last modification date: 2020-07-29)
Primary citation	Zheng, J.,Chen, L.,Skinner, O.S.,Ysselstein, D.,Remis, J.,Lansbury, P.,Skerlj, R.,Mrosek, M.,Heunisch, U.,Krapp, S.,Charrow, J.,Schwake, M.,Kelleher, N.L.,Silverman, R.B.,Krainc, D. beta-Glucocerebrosidase Modulators Promote Dimerization of beta-Glucocerebrosidase and Reveal an Allosteric Binding Site. J. Am. Chem. Soc., 140:5914-5924, 2018 Cited by PubMed: 29676907 DOI: 10.1021/jacs.7b13003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation