5LVX

Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator

5LVX の概要

• エントリーDOI: 10.2210/pdb5lvx/pdb
• 分子名称: Glucosylceramidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: gcase, hydrolase, glycoprotein, glycosidase, glucosylceramidase, prot, proteros biostructures gmbh
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 230629.43

構造登録者

Zheng, J.,Chen, L.,Skinner, O.S.,Lansbury, P.,Skerlj, R.,Mrosek, M.,Heunisch, U.,Krapp, S.,Weigand, S.,Charrow, J.,Schwake, M.,Kelleher, N.L.,Silverman, R.B.,Krainc, D. (登録日: 2016-09-14, 公開日: 2017-10-25, 最終更新日: 2020-07-29)

• 主引用文献: Zheng, J.,Chen, L.,Skinner, O.S.,Ysselstein, D.,Remis, J.,Lansbury, P.,Skerlj, R.,Mrosek, M.,Heunisch, U.,Krapp, S.,Charrow, J.,Schwake, M.,Kelleher, N.L.,Silverman, R.B.,Krainc, D.; beta-Glucocerebrosidase Modulators Promote Dimerization of beta-Glucocerebrosidase and Reveal an Allosteric Binding Site.; J. Am. Chem. Soc., 140:5914-5924, 2018; PubMed: 29676907; DOI: 10.1021/jacs.7b13003

実験手法

X-RAY DIFFRACTION (2.2 Å)