5LVR

Crystal structure of human PCAF bromodomain in complex with compound-E (CPD-E)

5LVR の概要

• エントリーDOI: 10.2210/pdb5lvr/pdb
• 分子名称: Histone acetyltransferase KAT2B, 1,2-ETHANEDIOL, 5-methyl-2-phenyl-1,2,3-triazole-4-carboxamide, ... (5 entities in total)
• 機能のキーワード: signaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc)
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q92831
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28997.50

構造登録者

Chaikuad, A.,Filippakopoulos, P.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Hopkins, A.L.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2016-09-14, 公開日: 2016-10-26, 最終更新日: 2017-01-11)

• 主引用文献: Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L.; Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.; ACS Med Chem Lett, 7:1213-1218, 2016; PubMed: 27994766; DOI: 10.1021/acsmedchemlett.6b00154

実験手法

X-RAY DIFFRACTION (2.05 Å)