5LUU

Structure of the first bromodomain of BRD4 with a pyrazolo[4,3-c]pyridin fragment

5LUU の概要

• エントリーDOI: 10.2210/pdb5luu/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propan-1-one, ... (4 entities in total)
• 機能のキーワード: fragment, complex, bromodomain, structural genomics, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15478.83

構造登録者

Filippakopoulos, P.,Picaud, S.,Knapp, S.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Structural Genomics Consortium (SGC) (登録日: 2016-09-11, 公開日: 2016-10-12, 最終更新日: 2017-11-08)

• 主引用文献: Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L.; Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.; ACS Med Chem Lett, 7:1213-1218, 2016; PubMed: 27994766; DOI: 10.1021/acsmedchemlett.6b00154

実験手法

X-RAY DIFFRACTION (1.61 Å)