5LUC

Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.8 Angstrom; internal aldimine with PLP in the active site

5LUC の概要

• エントリーDOI: 10.2210/pdb5luc/pdb
• 関連するPDBエントリー: 5F9S 5HHY
• 分子名称: Serine--pyruvate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: primary hyperoxaluria type i, ph1, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Peroxisome : P21549
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 357892.27

構造登録者

Giardina, G.,Cutruzzola, F.,Cellini, B.,Borri Voltattorni, C.,Montioli, R. (登録日: 2016-09-08, 公開日: 2017-09-20, 最終更新日: 2024-01-17)

• 主引用文献: Giardina, G.,Paiardini, A.,Montioli, R.,Cellini, B.,Voltattorni, C.B.,Cutruzzola, F.; Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.; Sci Rep, 7:11704-11704, 2017; PubMed: 28916765; DOI: 10.1038/s41598-017-11948-w

実験手法

X-RAY DIFFRACTION (1.8 Å)