5LS3

Crystal structure of metallo-beta-lactamase SPM-1 with Y58C mutation

Summary for 5LS3

• Entry DOI: 10.2210/pdb5ls3/pdb
• Descriptor: Beta-lactamase IMP-1, ZINC ION (3 entities in total)
• Functional Keywords: metallo-beta-lactamase, carbapenemase, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 56061.34

Authors

Hinchliffe, P.,Spencer, J. (deposition date: 2016-08-22, release date: 2017-03-15, Last modification date: 2024-01-17)

• Primary citation: Abboud, M.I.,Hinchliffe, P.,Brem, J.,Macsics, R.,Pfeffer, I.,Makena, A.,Umland, K.D.,Rydzik, A.M.,Li, G.B.,Spencer, J.,Claridge, T.D.,Schofield, C.J.; (19) F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the Sao Paulo Metallo-beta-Lactamase.; Angew. Chem. Int. Ed. Engl., 56:3862-3866, 2017; PubMed: 28252254; DOI: 10.1002/anie.201612185

Experimental method

X-RAY DIFFRACTION (1.754 Å)