5LR6

Crystal Structure of COMT in complex with [3-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone

Summary for 5LR6

• Entry DOI: 10.2210/pdb5lr6/pdb
• Descriptor: Catechol O-methyltransferase, [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1~{H}-pyrazol-3-yl]-(4-phenylpiperazin-1-yl)methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (5 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, transferase
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 4
• Total formula weight: 101218.17

Authors

Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-18, release date: 2016-08-31, Last modification date: 2024-05-01)

• Primary citation: Lerner, C.,Rudolph, M.G.; Crystal Structure of COMT in complex with [3-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone; To be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)