5LQN
Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole
Summary for 5LQN
Entry DOI | 10.2210/pdb5lqn/pdb |
Descriptor | Catechol O-methyltransferase, 2-[(3-chloranylphenoxy)methyl]-4-methyl-5-(1~{H}-pyrazol-5-yl)-1,3-thiazole (3 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, transferase |
Biological source | Rattus norvegicus (norway Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25000.11 |
Authors | Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-17, release date: 2016-10-05, Last modification date: 2024-05-01) |
Primary citation | Lerner, C.,Rudolph, M.G. Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole To be published, |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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