5LQN

Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole

5LQN の概要

• エントリーDOI: 10.2210/pdb5lqn/pdb
• 分子名称: Catechol O-methyltransferase, 2-[(3-chloranylphenoxy)methyl]-4-methyl-5-(1~{H}-pyrazol-5-yl)-1,3-thiazole (3 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase
• 由来する生物種: Rattus norvegicus (norway Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25000.11

構造登録者

Ehler, A.,Lerner, C.,Rudolph, M.G. (登録日: 2016-08-17, 公開日: 2016-10-05, 最終更新日: 2024-05-01)

• 主引用文献: Lerner, C.,Rudolph, M.G.; Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole; To be published,

実験手法

X-RAY DIFFRACTION (1.72 Å)