5LQA

rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor

5LQA の概要

• エントリーDOI: 10.2210/pdb5lqa/pdb
• 分子名称: Catechol O-methyltransferase, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ethylaminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide, ... (7 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25026.70

構造登録者

Ehler, A.,Ellermann, M.,Rudolph, M.G. (登録日: 2016-08-16, 公開日: 2016-10-05, 最終更新日: 2024-05-01)

• 主引用文献: Ellermann, M.,Rudolph, M.G.; rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor; To be published,

実験手法

X-RAY DIFFRACTION (1.2 Å)