5LOD

Crystal structure of HhaI DNA methyltransferase in APO form

5LOD の概要

• エントリーDOI: 10.2210/pdb5lod/pdb
• 分子名称: Modification methylase HhaI, SULFATE ION (3 entities in total)
• 機能のキーワード: m.hhai, c5-methylcytosine, apo form, dna methyltransferase, transferase
• 由来する生物種: Haemophilus parahaemolyticus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74564.73

構造登録者

Rondelet, G.,Wouters, J. (登録日: 2016-08-09, 公開日: 2017-08-16, 最終更新日: 2024-01-10)

主引用文献

Rondelet, G.,Fleury, L.,Faux, C.,Masson, V.,Dubois, J.,Arimondo, P.B.,Willems, L.,Wouters, J.
Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.
Future Med Chem, 9:1465-1481, 2017

PubMed Abstract: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activity in cancer cells and mode of action of these compounds remains unclear.

PubMed: 28795598
DOI: 10.4155/fmc-2017-0074

実験手法

X-RAY DIFFRACTION (1.9 Å)